Availability
- Request Lead Time
- In stock and ready for quick dispatch
Product Overview
Product Name | Anti-Granzyme B FITC |
---|---|
Catalog Number | GRP13258 |
Reactivity | Human, Primate |
Tested applications | FC |
Immunogen | Human NK cell line YT-INDY-derived granzyme B |
Alternative Names | (click to expand) |
Product Properties
Form/Appearance | FITC |
---|---|
Preservatives | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
Note | For research use only. |
Isotype | Mouse IgG1 |
Clone ID | CLB-GB11 |
Uniprot ID | P10144 |
NCBI | 3002 |
Product Description
Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.
Reviews
Write Your Own Review