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Product Overview
Product Name | Anti-Hu CD8 PE |
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Catalog Number | GRP13262 |
Reactivity | Human, Primate |
Tested applications | FC |
Immunogen | human blood lymphocytes |
Alternative Names | (click to expand) |
Product Properties
Form/Appearance | PE |
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Preservatives | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
Note | For research use only. |
Isotype | Mouse IgG1 |
Clone ID | LT8 |
Product Description
The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
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