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ATM antibody [2C1]

Catalog Number: GRP83

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Datasheet
Product Overview
Product Name ATM antibody [2C1]
Catalog Number GRP83
Species/Host Mouse
Reactivity Human, Mouse, Rat, Monkey
Conjugation Unconjugated
Tested applications ChIP, ELISA, FACS, ICC, IF, IHC-P, IP, WB
Immunogen Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
Alternative Names (click to expand) Atm Serine/Threonine Kinase | At1 | Ata | Atc | Atd | Atdc | Ate | Tel1 | Telo1 | Atm
Product Properties
Form/Appearance Liquid: PBS
Concentration 1 mg/ml
Storage Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Note For research use only.
Isotype IgG1
Clonality Monoclonal
Purity Purified by antigen-affinity chromatography.
Clone ID 2C1
Uniprot ID Q13315
Entrez 472
Product Description

The ATM antibody, clone 2C1, recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.

Validation Images
Human Testis (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Human Testis (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GRP535) by western blot or immunoprecipitation.
Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GRP535) by western blot or immunoprecipitation.
Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GRP535) diluted at 1:1000.
Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GRP535) diluted at 1:1000.
HeLa whole cell extract and nuclear extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GRP535) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody was used to detect the primary antibody.
HeLa whole cell extract and nuclear extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GRP535) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody was used to detect the primary antibody.
ATM antibody [2C1] detects ATM protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human breast carcinoma.ATM stained by ATM antibody [2C1] (GRP535) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
ATM antibody [2C1] detects ATM protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human breast carcinoma.ATM stained by ATM antibody [2C1] (GRP535) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
The WB analysis of ATM antibody [2C1] was published by Lee JH and colleagues in the journal PLoS One in 2014 .
The WB analysis of ATM antibody [2C1] was published by Lee JH and colleagues in the journal PLoS One in 2014 .
The WB analysis of ATM antibody [2C1] was published by Kongruttanachok N and colleagues in the journal Mol Cancer in 2010.PMID: 20356374
The WB analysis of ATM antibody [2C1] was published by Kongruttanachok N and colleagues in the journal Mol Cancer in 2010.PMID: 20356374
The WB analysis of ATM antibody [2C1] was published by He D and colleagues in the journal Sci Rep in 2016.PMID: 27074761
The WB analysis of ATM antibody [2C1] was published by He D and colleagues in the journal Sci Rep in 2016.PMID: 27074761
The WB analysis of ATM antibody [2C1] was published by Gibbs-Seymour I and colleagues in the journal Aging Cell in 2015.PMID: 25645366
The WB analysis of ATM antibody [2C1] was published by Gibbs-Seymour I and colleagues in the journal Aging Cell in 2015.PMID: 25645366
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