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Product Overview
| Product Name | MMP1 antibody |
|---|---|
| Catalog Number | GRP10 |
| Species/Host | Rabbit |
| Reactivity | Human, Mouse |
| Conjugation | Unconjugated |
| Tested applications | ICC, IF, IHC-P, WB |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MMP1. The exact sequence is proprietary. |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Liquid: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
|---|---|
| Concentration | 0.46 mg/ml |
| Storage | Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Purity | Purified by antigen-affinity chromatography. |
| Uniprot ID | P03956 |
| Entrez | 4312 |
Product Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq]
Application Notes
| Dilution Range | WB: 1:500-1:3000,IHC-P: 1:100-1:1000 |
|---|
Validation Images
Immunohistochemical analysis of paraffin-embedded human breast cancer, using MMP1(GRP462) antibody at 1:250 dilution.
MMP1 antibody detects MMP1 protein at secreted on human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. MMP1 antibody (GRP462) dilution: 1:500.
MMP1 antibody detects MMP1 protein at secreted on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. MMP1 antibody (GRP462) dilution: 1:500.
MMP1 antibody detects MMP1 protein at secreted on human cervical carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human cervical carcinoma. MMP1 antibody (GRP462) dilution: 1:500.
Whole cell extract (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with MMP1 antibody (GRP462) diluted at 1:2500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
The IHC-P analysis of MMP1 antibody was published by Dubey NK and colleagues in the journal Aging Dis in 2019 .
The WB analysis of MMP1 antibody was published by Dubey NK and colleagues in the journal Aging Dis in 2019 .
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