Availability
- Request Lead Time
- In stock and ready for quick dispatch
Transthyretin 56-61, amyloid specific (mouse monoclonal antibody)
Catalog Number: GRP12986
Product Overview
Product Name | Transthyretin 56-61, amyloid specific (mouse monoclonal antibody) |
---|---|
Catalog Number | GRP12986 |
Species/Host | Mouse |
Reactivity | Human |
Tested applications | ELISA, WB, IHC |
Immunogen | Recombinant protein corresponding to the Human wild type Transthyretin. GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE The epitope has been mapped to residue 56-61 |
Product Properties
Form/Appearance | Lyophilized |
---|---|
Storage | Store lyophilized/reconstituted at 4°C. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes. |
Note | For research use only. |
Isotype | IgG1 |
Clonality | Monoclonal |
Purity | Affinity purified |
MW | 155 |
Application Notes
Dilution Range | 1:1000 (ELISA), 1:500 (IHC), 1:1000 (WB) |
---|---|
Application Notes | Additional Information: Specifically reactive to the amyloid form of human Transthyretin. Epitope mapped to residue 56-61 which remains buried within the native fold of transthyretin but becomes exposed within its amyloid form.It has been suggested that that two distinct mechanisms of TTR-amyloidosis exists. The first, most common seen in wild type TTR Amyloidosis, consists of the full length TTR. Whereas the other type of amyloidosis mainly consists of the C-terminal region of the protein and is more common in mutant versions of TTR. Mouse IgG1 Anti-Transthyretin 56-61 (Amyloid Specific) epitope is located at the C-terminal strand of cleaved TTR and is suitable to detect amyloid formation derived from the C-terminal. Background: Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 10% of the population above 80 years of age with depositions mainly found in the heart.Monoclonal IgG1 antibody. Amyloid specific for human Transthyretin. Detects the C-terminal fragment 49-127 frequently formed in vivo. Reconstitution: Add 100 ul sterile water to reconstitute to 1 mg/ml. |
Reviews
Write Your Own Review